Wednesday 19/07/23
Section outline
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In this session we will discuss how all environmental exposures could be integrated in the concept of the "exposome". We will discuss ways they we can model and measure the exposome, how we can design exposome-wide association studies, the use of biosensors and wearables and the significance of the ditigal twins.
Further reading:
•Ding, E., Wang, Y., Liu, J. et al. A review on the application of the exposome paradigm to unveil the environmental determinants of age-related diseases. Hum Genomics 16, 54 (2022). https://doi.org/10.1186/s40246-022-00428-6•Münzel, T., Sørensen, M., Hahad, O. et al. The contribution of the exposome to the burden of cardiovascular disease. Nat Rev Cardiol (2023). https://doi.org/10.1038/s41569-023-00873-3•Armeni P, Polat I, De Rossi LM, Diaferia L, Meregalli S, Gatti A. Digital Twins in Healthcare: Is It the Beginning of a New Era of Evidence-Based Medicine? A Critical Review. J Pers Med. 2022 Jul 30;12(8):1255. https://doi.org/10.3390/jpm12081255•Ates, H.C., Nguyen, P.Q., Gonzalez-Macia, L. et al. End-to-end design of wearable sensors. Nat Rev Mater 7, 887–907 (2022). https://doi.org/10.1038/s41578-022-00460-x -
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In this journal club we will discuss this paper: The ethical aspects of exposome research: a systematic review https://academic.oup.com/exposome/article/3/1/osad004/7115840. We will look into different ethical aspects that might arise when we analyse the totality of environmental exposures and their corresponding biological responses within the human body. We will also discuss aspects of leveraging results of the exposome research to inform public guidelines and what is the best way to safeguard individuals' personal data.
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